【研究新知】如何在臺灣進行精準醫學研究How to Perform Precision Medicine Studies in Taiwan
主講人：中央研究院 生物醫學科學研究所 李永凌 副研究員
Airway neutrophils are associated with both asthma severity and acute exacerbations. Neutrophil extracellular traps (NETs) from neutrophils cause lung injury and their levels are increased in severe asthma. We analyzed the blood transcriptomes from children with controlled and uncontrolled asthma in Taiwanese Consortium of Childhood Asthma Study (TCCAS). Hierarchical clustering, differentially expressed gene (DEG), weighted gene co-expression network analysis (WGCNA) and pathway enrichment methods were performed to investigate important genes between two groups. NETs were measured from peripheral neutrophils and used to predict ICS response in asthma children. There were 298 uncontrolled asthma-specific DEGs and a gene module associated with neutrophil mediated immunity, neutrophil activation and neutrophil degranulation. Only the leukotriene receptor antagonist could significantly suppress the neutrophil gene module, compared to the groups of ICS or reliever use. In the TCCAS, NETs levels were significantly higher in ICS non-responders, compared with ICS responders.
The Taiwan Precision Medicine Initiative (TPMI) is a joint project between Academia Sinica and medical centers in Taiwan. By profiling 1 million participants with a set of genetic markers designed for Taiwan, here I would take pharmacogenomics examples for researchers to use TPMI in confirming the genotype-phenotype correlation.